In Corporate SINs
This is therefore one of the first memes associated to the show.
It is referenced, more or less explicitly, during runs when MMFEC encounter a bathroom or waste their time.
After going from trap to trap and receiving an unexpected message from Maris, the late Cromwell's tea lady, MMFE were unsurprisingly on their guard. That's when Mordecai told a fretting Fang:
Go buff in the bathroom if you have to.
This was followed by a bit of gallows humor, when it was remarked that:
In the Corporate Metagame
Reacting to the corporations all doing research with the optional +2 bonus and Zak's frustration about it, Dan remarked that they are buffing in the bathroom. A few minutes later, he added, unless it was really Mordecai speaking, that buffing makes sense.